Colorectal cancer and associated risk factors : case control hospital based study in Egypt

2024 | Vol-1 | Issue-1 | Date of Submission: | Date of Publication:

Abstract

Background: Colorectal cancer accounts for approximately 10% of all annually diagnosed cancers and cancer-related deaths worldwide.1 It is the second most common cancer diagnosed in women and third most in men. In women, incidence and mortality are approximately 25% lower than in men. These rates also vary geographically, with the highest rates seen in the most developed countries . With continuing progress in developing countries, the incidence of colorectal cancer worldwide is predicted to increase to 2·5 million new cases in 2035. Methods: Two hundreds a histopathologically confirmed colorectal cancer cases were recruited from Tanta university onchology department. 150 patients matched with age ,sex and social class were recruited as control group. Results: Multivariable conditional logistic regression model showed that cases were 3.9 times more likely to have had attainted obesity (BMI>=30) in their lifetime compared to controls (OR=3.9; 95% CI: 1.8-10.6). Compared to controls, cases rarely consumed fruits and vegetable OR =16.9; 95% CI: 6.5-48.5), tended to consume red meat 2-5 times a week (OR=4.7; 95% CI: 1.8-8.8) or more than 5 times a week (OR =10.8; 95% CI: 4.5-26.9).). Conclusions: Obesity, excessive red meat consumption and infrequent consumption fruits/vegetables intake were associated with an increased risk of colorectal cancer.